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Mechanism of cardiotoxicity CTX is a prodrug metabolized by hepatic cytochrome C 450 into 4-hydroxycyclophosphamide and aldocyclophosphamide, which decomposes into cytotoxic phosphoramide mustard and acrolein (107)
Roughly 12% of adults say that they have used a GLP-1 drug at some point
For patients with MCAS specifically, what piqued my interest in giving this class of medications a try was a case series in The American Journal of the Medical Sciences from mast cell experts, including doctors Afrin, Weinstock and Dempsey
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