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FIGURE 17 5 Conclusion The expression of GLP-1R in tissues other than the pancreas, such as the brain, endocrine tissues, heart muscle, kidneys, lungs, muscle, and vascular tissues, as well as the proximal digestive and gastrointestinal tract, indicates that GLP-1 has a multifaceted regulatory role beyond glucose homeostasis mediated by insulin release
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as an adjunct to standard of care therapy to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction or non-fatal stroke) in adults with established cardiovascular disease, with a BMI 27 kg/m 2 , and without established Type 1 or Type 2 diabetes
Massachusetts is keeping coverage for GLP-1 drugs to treat certain other conditions, including diabetes
