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From a practical standpoint, the measurable LIP is defined as the pool of iron that is accessible to weak iron chelators introduced to the cytosol (Petrat et al., 2002)
N Engl J Med 373(1):1122 Ramesh N, Mortazavi S, Unniappan S (2016) Nesfatin-1 stimulates cholecystokinin and suppresses peptide YY expression and secretion in mice
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This acylation method increases the cellular half-life from minutes (native amylin) to several days, which allows the drug to be given only once a week
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