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(A) Metabolites (phosphatidylcholines, sphingomyelins, acylcarnitines) showing differential patterns in the serum of mice aged 2 (n = 2), 4 (n = 3), 14 (n = 2), and 21 months (n = 3)

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Each dose increase is essentially another disruption to the gut microbiome, and the probiotic support that helped you through the previous adjustment is no longer there

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