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For tesamorelin, known adverse effects (based on US and Canadian prescribing information, as no UK Summary of Product Characteristics exists) include: Fluid retention (oedema, joint pain, carpal tunnel syndrome) Elevated blood glucose and reduced insulin sensitivity due to GH elevation Injection site reactions Raised IGF-1 levels active malignancy is a key contraindication
These drugs hold the potential to help address what continues to be an increasing obesity problem in the US
For serious cases, more steps might be needed
Presented for research literature review only McIlwain CC et al
Overactive Rap1 can disrupt glucose control
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