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In the landmark SURPASS-2 trial published in the New England Journal of Medicine, tirzepatide at its highest dose (15 mg) achieved roughly double the weight reduction of semaglutide 1 mg at 40 weeks

This positive feedback loop promotes Wnt target gene expression, autophagy activation, drug efflux, and gemcitabine resistance

Supplemental creatine may reduce the need to manufacture creatine from SAM, conserving methyl groups and reducing SAH generation from endogenous creatine synthesis

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The rest of the parameters were set as the default, which included precursor FDR set to 1% and peptide length of 730 amino acids