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Tirzepatide has a different side effect profile, and many people who struggled with semaglutide find tirzepatide more tolerable, though the reverse can also be true
Due to differences in mechanisms, dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonists were not included in the definition of GLP-1 RAs users in this study [35,36,37]
10.1038/s41409-021-01233-w 179
Nonetheless, for completeness and interpretive purposes, studies using animal models are included in this review and are explicitly described as such herein
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