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For OCTN2, D139N is a variant potentially associated with SPCD that does localise correctly to the membrane, but does not impair transport activity in uptake assays 11
The Evidence: Where They Differ Significantly This is the most important part of the comparison, and where the two options diverge most sharply
Those with mild Crohns can eat and function reasonably normally, while those with severe disease often fail to respond to conventional treatment and have persistent gastrointestinal symptoms, as well as fevers, and infections
RTqPCR Total RNA was isolated using the RNeasy Mini Kit (Qiagen, 74104) and reverse-transcribed with a high-capacity RNA-to-cDNA kit (Vazyme, R323-01)
L.MokrzanE
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