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[209] [204] [195] Amphetamine's effect on intracellular calcium is associated with DAT phosphorylation through Ca 2+ /calmodulin-dependent protein kinase II alpha (CAMKII), in turn producing dopamine efflux

What they found: Melanotan II is 100 to 1000 more potent than native -MSH in melanocyte assays Cyclization preserves the active conformation longer than linear -MSH Activates all four functional melanocortin receptors (MC1R, MC3R, MC4R, MC5R) In vivo: visible pigmentation of lizard skin within hours, not days as with -MSH Why it matters: This is the foundational publication of Melanotan II

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Further investigation revealed that irisin, through SIRT1 regulation, reduced lactate synthesis and apoptosis by inhibiting lactate metabolism-related genes