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Developing tirzepatide required years of large-scale clinical trials, including the SURMOUNT trial program, which ran across thousands of participants over multiple years before FDA approval was granted
From 5 October 2018 to 1 February 2019, 304 participants were randomly assigned to semaglutide 2.4 mg (n = 152) or placebo (n = 152), 92.8% of whom completed the trial (attended the end-of-trial safety visit)
WEGOVY (Semaglutide) Prescribing Information (US Food and Drug Administration, 2022)
Hui et al., 2025)
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