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2- Buchner A, Merrel PW, Carpenter WM
In the first, test subjects aged between 20 and 40 were enrolled
The protocol: Reduce sulfonylurea dose by 50% when starting semaglutide Monitor blood glucose before meals and at bedtime for 2 weeks Many patients discontinue sulfonylureas entirely within 4 to 8 weeks as semaglutide reaches therapeutic levels The SUSTAIN-2 trial (Ahrn et al., Diabetes Care , 2018) showed that 41% of patients on sulfonylureas plus semaglutide experienced hypoglycemia, compared to 11% on semaglutide alone
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