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Proven 20% MACE reduction in SELECT (obesity) and 26% in SUSTAIN 6 (T2D), while exenatide only achieved non-inferiority in EXSCEL
Also cardiovascular benefits
The safety profile was consistent with previous studies, with gastrointestinal symptoms being the most common adverse effects
Gut friendly foods for GLP-1 users include high-fiber options to combat constipation (such as cooked vegetables, berries, oats, and lentils), and probiotic-rich foods (like plain Greek yogurt or kefir)
However, a pooled analysis of the two trials that employed ALCAR found no significant effect of ALCAR and L-carnitine on sperm concentration, motility, and morphology (114)
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