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LCN2 is a secreted siderophore-binding protein that can capture iron-containing complexes in iron-poor niches and deliver iron to cancer cells via specific receptors (e.g., SLC22A17/24p3R), thereby supporting tumor cell survival and proliferation under limiting-iron conditions ( Hepcidin, an essential hormone regulating systemic iron homeostasis, is a hepatic peptide widely regarded as a primary iron regulator ( Pro-inflammatory cytokinessuch as IL-6, IL-1, TNF-, and IFN-can further upregulate hepcidin, disrupting the FPN/Hepcidin pathway and inhibiting iron export, thus affecting iron levels in the body

Bruen R, Curley S, Kajani S, Crean D, O'Reilly ME, Lucitt MB, Godson CG, McGillicuddy FC, Belton O