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Currently, there is an active clinical trial to assess the effect of simvastatin on central nervous system vasculature in patients with SCD (ClinicalTrials.gov Identifier: NCT03599609)
It is initiated during the ischemia stage due to energy metabolism disorders and further amplified during the reperfusion stage due to a surge in ROS, severely disrupting cellular homeostasis and organ function
Nausea, reduced appetite, and changes in food preferences typically stem from GLP-1 receptor activation in the appetite centers
Future research should prioritize longitudinal cohort studies with precise exposure metrics, integrated with mechanistic experiments to bridge the critical gap between animal models and human pathophysiology
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