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Sharp right upper abdominal pain, particularly after fatty meals, suggests gallbladder issues
Importantly, this region contributes much less to receptor binding than to binding-protein binding, which is what makes the modification useful: it separates the two interactions rather than weakening both
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In contrast, metabolites such as phosphatidic acid, phosphatidylglycerol (16:0/0:0), PC (16:0/3:1(2E)), and phosphatidylinositol (16:0/16:0) are significantly upregulated, suggesting a high saturation of glycerophospholipids
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