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Holly Wyatt, profesora adjunta asociada en Medicina en la Universidad de Colorado Anschutz
Metformin-induced lactate production in rats was found to be most concentrated in the hepatic portal vein, accompanied by a decrease in glucose levels, indicating that the gastrointestinal tract is the primary location for glucose consumption and lactate generation following metformin administration (Bailey et al., 1992)
Consistent with other GLP1R agonists, nausea, diarrhea and vomiting are common side-effects, with no long-term harms noted from Trulicity over its 9 year use in the markets
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Most mild reactions improve within one week of continued use or dose reduction
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