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The 2025 narrative review noted that despite the volume of preclinical work, well-controlled human trial data are scarce, and the regenerative findings should be interpreted accordingly (PMID 40789979)
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In one representative experiment, rats treated with indomethacin to induce severe gastric lesions showed near-complete mucosal restoration within five days of BPC-157 administration, compared to ongoing lesion progression in untreated controls
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Although there are no studies that have specifically examined the effects of CGRP on muc5AC or muc5B expression in COPD, finding altered CGRP receptor expression in COPD airway epithelial cells suggests a possible influence of CGRP on muc5AC and muc5B expression
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