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A recent meta-analysis pooled available observational cohorts and registry studies to evaluate IBD clinical outcomes (hospitalisation, surgery, steroid use, escalation to advanced therapies) [4]
In addition, there are a few conserved residues (e.g., Asp67, Trp72, Pro86, Gly108, and Trp110) that form specific interactions within the extracellular domain (see Figure 4 insets)
However, high-dose antioxidant supplementation, even from natural sources, may pose risks
Animal studies have shown potential risks to the fetus
The aim is to prevent inadvertent exposure during the first trimester
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