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NICE recommends it (Technology Appraisal TA875) for adults with a BMI of 35 kg/m or above with at least one weight-related comorbidity, or a BMI of 3034.9 kg/m in certain higher-risk groups, when used within a specialist Tier 3 or Tier 4 weight management service alongside a reduced-calorie diet and increased physical activity
"We are very clear on how obesity works and the fact that it is a relapsing medical condition and one that is with the patient for their whole life
Frontiers in Endocrinology, 12 , 666687
( I ) Food intake (kcal/h) in HFD-fed PAR2-G37I and WT mice
## Storage After Reconstitution - **Refrigerate** at 36-46 degrees F (2-8 degrees C) immediately after reconstitution - **Use within 28-30 days** - **Protect from light** -- store in the original box or wrap in foil - **Never freeze** reconstituted solution - **Check before each use** -- if cloudy, discolored, or containing particles, discard ### Before Reconstitution (Unreconstituted Powder) - Refrigerate or store at controlled room temperature per the label - Check expiration date - Keep dry and protected from moisture ## Injection Technique ### Preparing Your Dose 1
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