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Presented for research literature review only Larsen ES et al

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This suggests that risperidone's metabolic side effects are largely driven by changes in gut microbes, opening up the possibility of targeting the microbiome to prevent or reduce weight gain in patients taking this medication

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In particular, the initial burst of superoxide that cannot be eliminated efficiently due to the inactivity of SOD1 is promptly buffered by the induction of GSH synthesis resulting in protection against oxidative stress and cell death

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