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Semaglutides effects on alcohol consumption appears larger than other existing FDA-approved medications for alcohol use. Questions remaining This was only a phase II trial with a relatively small sample size, so more data is needed to verify these findings and better understand the potential of GLP-1 therapy as a treatment for substance use disorders
ROC plots have been popularly used to assess the utility of biomarkers by comparing the AUC for predictive models with and without the biomarker (Alemayehu and Zou 2012)
Small mechanistic studies hint at additive benefits when GLP-1RA are paired with SGLT2i or non-steroidal mineralocorticoid-receptor antagonists
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