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These canonical functions positioned DHODH primarily as a metabolic enzyme critical for nucleotide biosynthesis and cellular proliferation, before its more recent identification as a mitochondria-specific ferroptosis suppressor in select cancer contexts
Patel: Thats what Im doing
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
80 XuD.SuC.SongX.ShiQ.FuJ.HuL.et al (2015)
Off-spec product is not: Trace iron, copper, or manganese catalyze oxidation of Met, Cys, Trp, and Tyr residues
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