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Genes Cancer 2 , 10611066 (2011)
The dosing ramps up across the first cycle: Days 1 through 15: 4 units (1 mg/day) Days 16 through 30: 8 units (2 mg/day) After 30 days, patients take 30 days off before starting the next cycle
Several approaches are being investigated to overcome this limitation
The dosing structure below is community-derived from each compound's Phase 2/3 data plus the Valdecantos 2024 preclinical synergy paper
Node degree was one of the primary methods used to identify key nodes, with higher node degrees signifying greater importance in the network
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