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Among those states that don't cover the drugs, half reported that they are considering adding coverage in the near future, the researchers added

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Injecting the solution slowly over 10-30 seconds to minimize discomfort and tissue irritation

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This underdiagnosis can lead, besides death in 20% when it is not appropriately treated, to Korsakoffs syndrome, a severe dysfunction often following untreated Wernickes encephalopathy, that does not remit even with thiamine treatment and is associated with chronic alcohol abuse and chronic thiamine deficiency (5, 6, 11, 28)