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However, a small percentage of the population may still encounter problems from chronic acetaminophen usage or high doses

Copper cycles between the divalent and monovalent states and, in the presence of a reductant and any peroxide, participates in Fenton-type chemistry that generates hydroxyl radicals

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However, the choice of copper compound remains important

"Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions"