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These interactions strengthen the binding and function of GLP-2, consistent with the decreased potencies of R242A (by 5-fold), R242E (by 20-fold), W249A (by 1552-fold) and Y252A (by 5-fold) (Fig

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As Phase 3 trials for retatrutide complete and more data becomes available, researchers will have a clearer picture of how these compounds compare in larger populations over longer durations