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Patients taking oral contraceptives should use backup contraception for 4 weeks after initiation and each dose increase due to potential reduced efficacy
This helps patients continue to pursue the life they desire, even though they still will face negative experiences
In the REDEFINE study series, the cagrilintide-semaglutide combination (CagriSema) led to 15.7% weight loss over 32 weeks, with cagrilintide powder included in the formulation
Use whichever standard allows you to maintain adequate rotation across your available injection area
There are also important contraindications: people with a personal or family history of certain thyroid tumors typically avoid GLP1 receptor agonists because of rodent data, and semaglutide interacts with insulin and insulin secretagogues in ways that may increase hypoglycemia risk
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