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Multiple dark spots that appeared together and have been stable are much less concerning than one spot that is enlarging, but the same two-week rule applies if they persist

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Future risks remain unclear, especially in people with a history of cancer or vascular issues

In most cases, the condition is self-limited and responds to supportive care and symptomatic relief including rest, elevation if a dependent extremity is affected, and use of compression stockings

It is intended for patients who are treatment-naive or who have already been exposed to prior endothelin receptor antagonist and phosphodiesterase 5 inhibitors