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Ethics declarations Ethics approval and consent to participate The animal study was reviewed and approved by Experimental Animal Center of Wenzhou Medical University (Approval ID: wydw2022-0032)

Concerta : This CNS stimulant is also prescribed for ADHD in both adults and children, and the extended-release formulation can provide symptom relief for up to 12 hours.[4] Due to the CNS effects of this prescription stimulant, it is classified as a Schedule II controlled substance with a high potential for dependence and addiction

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5.1 Major Weight Loss Trials (Semaglutide) The STEP (Semaglutide Treatment Effect in People with obesity) programme demonstrated substantial weight reduction with once-weekly semaglutide. Key findings: Mean weight loss of ~15% body weight Reduced caloric intake Gastrointestinal side effects most common during dose escalation Micronutrient levels were not systematically reported as primary outcomes

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