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Based on these findings, we next aimed to characterize the concentration-dependent cholesterol-lowering properties of the lead compounds 3 , 6 , 9 and 10
Generally, the synthesis of melanin is a complex process, with a multitude of genes influencing its production, such as tyrosinase-related protein 1 ( TRP-1 ), glycogen synthase kinase-3 beta ( GSK3 ), -catenin , cyclic adenosine monophosphate ( cAMP ), cAMP-response element binding protein ( CREB ), and solute carrier family 7 member 11 ( SLC7A11 ) [93, 185, 228]
The DEG threshold was set at q 0.05, and |log2_ratio | 1
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By selectively inhibiting VEGF receptor activation, semaxinib offered a targeted approach to modulating vascular dynamics and potentially attenuating disease progression
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