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These are model-based observations

Overgaard RV, Delff PH, Petri KCC, Anderson TW, Flint A, Ingwersen SH

At six months, people taking bupropion were 15-20% less likely to gain a clinically significant amount of weight (5% or more of their baseline) than those taking sertraline, the most commonly prescribed antidepressant.1 Some bupropion users actually lost a small amount, about half a pound on average at six months, though this reversed to a modest 1.2-pound gain by 24 months

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