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Notch receptor mutants were first discovered in Drosophila and named based on the dominant notched wing phenotype observed 40
This suggests a temporary effect on blood pressure regulation or hydration status rather than a direct neurological impact
Adems, las neuronas del NTS, que recogen aferencias de origen perifrico, sintetizan pre-proglucagn y son fuente de GLP-1 en el propio SNC, que alcanza mediante vas neuronales receptores especficos localizados en estructuras clave en el control de la ingesta, como el ncleo paraventricular, el septo lateral, el ncleo accumbens y el ncleo parabraquial lateral2,3,6
This review summarizes recent advances in GLP-1R-targeted nanoplatforms, including lipid nanoparticles, polymeric carriers, inorganic nanoparticles, and biomimetic scaffolds that improve peptide stability, prolong circulation half-life, and enable selective tissue targeting
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