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Therefore, therapeutic agents capable of mitigating oxidative damage are of significant interest

In a Phase 2, randomised, placebo-controlled trial published in the New England Journal of Medicine , participants received different retatrutide doses or placebo for 48 weeks

Main Text Glucagon-like peptide-1 (GLP-1), a neuroendocrine hormone, is derived from a proglucagon precursor ( 1 ) and secreted by intestinal enteroendocrine L cells in response to nutrient intake ( 2 ), predominantly in the form of GLP-1(7-36) amide (henceforth GLP-1) ( 3 )

No serious adverse events reported

Mounjaro Foundayo (orforglipron) is a once-daily oral GLP-1 medication