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Unlike cyanocobalamin, mecobalamin directly participates in nerve regeneration and myelin sheath repair , making it ideal for treating diabetic neuropathy , peripheral neuropathy , anemia , fatigue , and tingling sensations

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Patients found to have a low serum cobalamin level in the absence of anaemia and who do not have food malabsorption or other causes of deficiency, should be tested for IFAB to clarify whether they have an early or latent presentation of pernicious anaemia

The primary limitation remains the lack of published human clinical trials