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In a randomized trial of semaglutide 2.4 mg vs placebo for 1 year, 529 participants with HFpEF with a BMI of 30 kg/m2, there was a very large reduction in symptoms, improvement in exercise function in the GLP-1 drug assigned group
This can be particularly helpful if you are very sensitive to dose increases or if you need to titrate (adjust) more slowly after a missed dose
If anything, the opposite appears to be occurring
Studies show that GLP-1s decrease pain/stiffness, protect cartilage, and improve mobility, possibly preventing surgery for some
S.KannaiahS.RajuP.GovindanL.MutumS
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