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(2014) 6:222ra18
Study population We included all patients registered as having type 2 diabetes in the National Diabetes Register who filled their first prescription for a GLP-1 receptor agonist, and, in a separate cohort, all patients registered as having type 2 diabetes in the National Diabetes Register who filled their first prescription for an SGLT2 inhibitor, between 1 January 2017 and 31 December 2021 (ensuring a minimum of 1-year follow-up until the end of the study period on 31 December 2022)
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Thus, key metabolic and neurobehavioral dysregulations of BBS were effectively recapitulated in Bbs5 / mice, which offer a robust platform for dissecting BBS pathophysiology and developing potential therapeutic strategies
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