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Step 3: Follow the standard semaglutide titration: Weeks 14: 0.25mg Weeks 58: 0.5mg Weeks 912: 1.0mg Continue increasing as needed (1.7mg, then 2.4mg for Wegovy) Important consideration: Patients switching from tirzepatide to semaglutide may notice reduced appetite suppression initially, because they're losing the GIP receptor component and starting at a sub-therapeutic semaglutide dose

CL Answer Supplements to Take or Avoid When Using a GLP-1 Drug Certain supplements may be helpful when taking a GLP-1 agonist, but others should be used with caution or avoided

Hepatology 74 , 474482 (2021)

Alimentary Pharmacology & Therapeutics, 19(5), pp.583590