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Reducing GSH biosynthesis generates replication stress in T315I-Bcr-Abl-32D cells that require dTTP/dCTP synthesis for survival, thus enabling JMF4073 susceptibility
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5.2 Pharmacodynamic properties Glutathione (GSH) and its metabolites also interface with energetics and neurotransmitter synthesis, through several prominent metabolic pathways
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Randomisation was 21:3:3:7 to cagrilintidesemaglutide 2.4/2.4 mg (n=2108), semaglutide 2.4 mg alone (n=302), cagrilintide 2.4 mg alone (n=302), or placebo (n=705), all with lifestyle intervention [7]
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