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Pharmacological management requires careful consideration in patients with diabetes: NSAIDs (such as ibuprofen or naproxen) are first-line when medication is needed and not contraindicated

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Male SD rats were administered a single IM injection of blank solvent (excipient), and biological samples, including whole blood, plasma, urine, feces, and tissues, were collected for background control

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On the other hand, DSIP and CBBBP show no improvement when compared with the model group (Figure 8A)