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(2021) 22(Suppl 4):e13239
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The biological rationale for combining these two peptides is mechanistic complementarity
Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase
However, three subsequent randomized control trials reported a neutral effect in airway inflammation with both available TZDs, pioglitazone and rosiglitazone
Future directions emphasize multifunctional theranostic nanoparticles that combine imaging agents and therapeutics, alongside scalable fabrication methods, to accelerate clinical translation
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