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When activated, brown adipocytes uncouple oxidative phosphorylation, burning fatty acids and glucose to generate heat rather than ATP
Alternatively, 1000mcg SC/MC can be given every day for 2-7 days, followed by maintenance treatment
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FDA's 2024 review states the mechanism of action is still unknown, which limits how confidently any specific physiological effect can be predicted in humans
Hydroxocobalamin tends to remain in the body longer and is more readily converted to the active coenzyme forms of B, which can make it effective for maintaining B levels
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