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For instance, some groups have investigated the immunogenicity of zeolitic imidazolate framework-8 (ZIF-8) nanoparticles in tumor therapy and found that ZIF-8 nanoparticles can induce pyroptosis through the caspase-1/GSDMD pathway, leading to cancer cell necrosis, reprograming of the tumor microenvironment and activation of antitumor immunity (Li J

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