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However, some secondary measures of nerve impairment did improve, especially in participants with higher cardiovascular risk and moderate BMI.7 Shorter-term trials have shown that 600mg/day of oral racemic ALA reduced neuropathy symptoms like burning, tingling, and numbness in as little as 35 weeks.4 20 A 2010 meta-analysis concluded that oral ALA can improve symptoms of diabetic neuropathy, but noted variability in effect sizes across trials and better results with intravenous administration.1 Despite promising results from some trials, a recent systematic review evaluating eight randomized controlled trials indicates that findings on ALA's effectiveness in treating diabetic neuropathy symptoms are inconsistent.23 While ALA proved safe and tolerable across these studies, the review concluded that definitive evidence supporting significant benefits is limited

Instead, the field should ask whether the correct patients, product potency, route, dose, timing and endpoint were aligned

Leonard, et al., Editors

I can look for certain benefits or ingredients and get a richer formula than what goes on the rest of my face (my skin is combination and some areas are oily)

Dosage, Concentration, Route of Administration Dosage: Seek advice from a licensed physician, medical director, or other healthcare provider Concentration (per mL): Methionine 25mg, Inositol 50mg, Choline 50mg, B6 0.175mg, Cyano 1mg Route of Administration: IM/SQ Resources: Tutorial: How to Open Your Medication Vial Not sure how to administer this medication