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GLP-1 receptor agonists promote weight loss through reduced appetite, increased feelings of fullness, and delayed gastric emptying
SURMOUNT-5 participants who lost at least 5% of their body weight and had less than 5% weight change in the final 12 weeks of the study were invited to continue into the ATTAIN-MAINTAIN phase 3 trial, where participants were randomly assigned 3:2 to once-daily orforglipron (Foundayo, Eli Lilly) or placebo for 1 year
Step 2 Melanin pathway modulation: L Glutathione is believed to help shift melanin production toward a lighter pigment type, contributing to a brighter overall tone with regular use
The addition of the GIP hormone appears to create a synergistic effect that supports deeper fat loss and better blood sugar regulation
At Centra Internal Medicine, we start tirzepatide at a low dose and gradually increase it to minimize potential side effects and help your body adjust
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