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Compounds used for in vivo experiments were further purified by size exclusion chromatography using a HiLoad Superdex 200 pg column (GE Healthcare) and further characterised for endotoxin level using the LAL Kinetic-QCL (Lonza) and integrity by LC/MS using an Acquity UPLC system coupled to a Synapt G1 mass spectrometer (Waters)
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Participants taking the highest approved 25mg dose lost an average of 17% of their starting body weight over 64 weeks, when used alongside a reduced-calorie diet and increased physical activity, and treatment was taken as intended
GLP-1 medications may indirectly help with Hashimotos Chronic inflammation is a core feature of Hashimotos
The oral formulation was associated with mild GI symptoms (nausea, loose stools) at rates similar to placebo
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