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The 670 who reached randomization had lost a mean 20.9%
This is one area where the triple agonist approach clearly outperforms dual agonism
Severe constipation : No bowel movement for more than 34 days despite home management, or inability to pass gas
The 12 mg dose produced a mean weight reduction of 24.2%, with 26% of participants losing 30% or more of their body weight [5]
With the advent of these new drugs, it is likely that our specialty will see these patients and they may ask why there is this risk
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