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That matters when reading the safety numbers the trial population was healthier than the general population that would actually seek the drug
however, because this was a retrospective target trial emulation with a relatively small number of events, it is not yet practice-changing and should instead be viewed as a signal that supports further research into the role of GLP-1 receptor agonists in epileptogenesis. Limitations and future directions The authors emphasised that the study design was observational, despite using advanced statistical methods to emulate a clinical trial
Gastroparesis Profound slowing of gastric emptying could potentially lead to severe gastroparesis, particularly at high doses or in susceptible individuals
It is best to use only one GLP-1 treatment at a time
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