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Adverse Effects Electrolyte imbalance: hypokalemia, hyponatremia, hypocalcemia Dehydration and hypotension Ototoxicity (especially with rapid IV administration or with aminoglycosides) Hyperuricemia may precipitate gout Hyperglycemia (mild) Contraindications Severe electrolyte depletion (e.g., hypokalemia, hyponatremia) Anuria (no urine output) Hypersensitivity to sulfonamides (use with caution) Drug Interactions Aminoglycosides: risk of ototoxicity Digoxin: risk of digoxin toxicity due to hypokalemia NSAIDs: reduce diuretic effect Other antihypertensives: additive hypotensive effects Key Counseling Points Take in the morning to avoid nighttime urination

For others, symptoms may be triggered by specific foods, meal size, alcohol, greasy foods, or rapid dose escalation

Because this was a narrative review rather than a systematic review or meta-analysis, the authors did not conduct a formal risk-of-bias assessment

We detected ACTL6A protein expression of 48 GC samples, those higher than the upper quartile are defined as high ACTL6A group, and those lower than the lower quartile are defined as low ACTL6A group

This maintenance state requires significantly less pharmaceutical intervention than the active loss phase