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274 , R1236R1242 (1998)
With the development of genetic testing technologies such as genome-wide association studies (GWAS) and next-generation sequencing (NGS), it has been discovered that approximately 127 locus abnormalities in the human genome are associated with the onset and progression of obesity [4] , as along with more than 550 monogenic mutations related to obesity [5]
This 5:1:1:1 ratio is not arbitrary
The enthusiastic claims circulating online frequently overstate what the research actually shows, and a responsible provider should be candid about the gap between physiologic plausibility and clinical proof
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