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Lack of Long-Term Data: While Semaglutide shows promise, more long-term studies are needed to fully understand its effects on kidney health, especially in individuals with advanced kidney disease

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Further studies to investigate this later possibility, including examination of the effect of GLP-1R in -cell lipid metabolism and mitochondrial nutrient utilisation under normal and glucolipotoxic stress conditions are warranted, as well as the investigation of the in vivo role of SPHKAP in GLP-1R-dependent glucoregulation

The research team conducted a systematic review of scientific literature published since 2015

During the first two to four weeks, participants in trials have reported: Gastrointestinal effects: Nausea, vomiting, diarrhoea, constipation, and abdominal discomfort are among the most commonly reported side effects